Associate Director Price Family Foundation Institute of Structural Biology Junior Investigator Oklahoma COBRE in Structural Biology
2021 Stephenson Research and Technology Center
101 David L. Boren Blvd.
B. Sc., Murray State University, 1999
Ph.D., Southern Illinois University, 2003
NSF Postdoctoral Fellow, Ohio State University, 2003-2007
Karr Lab Website
Research areas: Microbiology, Molecular and Cellular Biology, Environmental Science, Anaerobic Microbiology
My primary research interests involve understanding the regulation of gene expression in the archaeal domain of life. Of particular interest are methanogenic archaea. Their environmentally important and dedicated metabolism, along with transcription mechanisms based on both eukaryotic and bacterial components make them ideal organisms in which to study transcription level regulation in response to ever changing environmental conditions. Our current focus involves the regulation of oxidative stress responses in strictly anaerobic methanogens. Recently we discovered a regulator, MsvR, which appears to be involved in such responses in select methanogens.
Sheehan, R., A. C. McCarver, A.C., C.E. Isom, E.A. Karr and D.J. Lessner. 2015. The Methanosarcina acetivorans thioredoxin system activates DNA binding of the redox-sensitive transcriptional regulator MsvR. Journal of Industrial Microbiology and Biotechnology. 42: 965-969.
Karr, E. A. 2014. Transcription Regulation in the Third Domain. Advances in Applied Microbiology. 89:101-133.
Isom, C. E., J. L. Turner, D. J. Lessner and E. A. Karr. 2013. Redox-sensitive DNA binding by homodimeric Methanosarcina acetivorans MsvR is modulated by cysteine residues. BMC Microbiology. 13, 163.
Islam, S. K. and E. A. Karr. 2013. Examination of metal corrosion by Desulfomicrobium thermophilum, Archaeoglobus fulgidus, and Methanothermobacter thermautotrophicus. BIOS. 84(2) 59-64.
Karr, E. A. 2010. The methanogen-specific transcription factor MsvR regulates the adjacent fpaA-rlp-rub oxidative stress operon in Methanothermobacter thermautotrophicus. J. Bacteriol. 192 5914-5922.